Jiangping He

Email: HE_JIANGPING@gzlab.ac.cn

CURRENT POSITION AND EDUCATION

Aug. 2022 - Present
Principal Investigator
Guangzhou Laboratory

May 2020 - Jul. 2022
Associate Investigator
BioLand Laboratory

Jul. 2019 - Apr. 2020
Assistant Investigator
BioLand Laboratory

Sep. 2014 - Jun. 2019
Ph.D. in stem cell biology
Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Science (CAS)

PUBLICATIONS

(#Equal contribution, *Correspondence author)

2022
  • WuF., LiufuZ., LiuY., GuoL., WuJ., CaoS., QinY., GuoN., FuY., LiuH., LiQ., Shu X., Pei D., Hutchins A.P., Chen J.*, He J.* Species-specific rewiring of definitive endoderm developmental gene activation via endogenous retroviruses through TET1-mediated demethylation. Cell Reports.

  • Yu S.#, Zhou C.#, He J.#, Yao Z., Huang X., Rong B., Zhu H., Wang S., Chen S., Wang X., Cai B., Zhao G., Chen Y., Xiao L., Liu H., Qin Y., Guo J., Wu H., Zhang Z., Zhang M., Zhao X., Lan F., Wang Y., Chen J., Cao S., Pei D., Liu J., BMP4 drives primed to naïve transition through PGC-like state. Nature Communications,.

    • 2021
  • He J., Babarinde I., Sun L., Xu S., Chen R., Shi J., Wei Y., Li Y., Ma G., Zhuang Q., Hutchins A.P., Chen J., Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE. Nature Communications.

  • Liu J.#, Gao M.#,He J#., Wu K., Lin S., Jin L., Chen Y., Liu H., Xu S., Lin Y., Zhao Y., Wu G., Zhang X., Luo G., Pei D., Wang J., Bao X., Chen J., The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature.

  • Ren X.#, We W.#, Fan X.#, Hou W.#, Su B.#, Cai P.#, Li J.#, Liu Y.#, Tang F.#, Zhang F.#, Yang Y.#, He J#. , Ma W.#, He J.#, Wang P.#, Cao Q., Chen F., Chen Y., Cheng X., Deng G., Deng X., Ding W., Feng Y., Gan R., Guo C., Guo W., He S., Jiang C., Liang J., Li Y., Lin J., Ling Y., Liu H., Liu J., Liu N., Liu Y., Luo M., Ma Q., Song Q., Sun W., Wang G., Wang F., Wang Y., Wen X., Wu Q., Xu G., Xie X., Xiong X., Xing X., Xu H., Yin C., Yu D., Yu K., Yuan J., Zhang B., Zhang T., Zhao J., Zhao P., Zhou J., Zhou W., Zhong S., Zhong X., Zhang S., Zhu L., Zhu P., Zou B., Zou J., Zuo Z., Bai F., Huang X., Bian X., Zhou P., Jiang Q., Huang Z., Bei J., Wei L., Liu X., Cheng T., Li X., Zhao P., Wang F., Wang H., Su B., Zhang Z., Qu K., Wang X., Chen J., Jin R., Zhang Z., COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell.

    • 2020
  • Sun J.#, Zhuang Z.#, Zhen J.#, Li K.#, Wong R.#, Liu D.#, Huang J.#, He J#., Zhu A.#, Zhao J.#, Li X.#, Xi Y.#, Chen R., Alshukairi A., Chen Z., Zhang Z., Chen C., Huang X., Li F., Lai X., Chen D., Wen L., Zhuo J., Zhang Y., Wang Y., Huang S., Dai J., Shi Y., Zheng K., Leidinger M., Chen J., Li Y., Zhong N., Meyerholz D., Jr. Paul B., Perlman S., Zhao J., Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment. Cell.

  • Yu S.#, Zhou C.#, Cao S.#, He J.#, Cai B., Wu K., Qin Y., Huang X., Xiao L., Ye J., Xu S., Xie W., Kuang J., Chu S., Guo J., Liu H., Pang W., Guo L., Zeng M., Wang X., Luo R., Li C., Zhao G., Wang B., Wu L., Chen J., Liu J., Pei D., BMP4 Resets Mouse Epiblast Stem Cells to Naïve Pluripotency through Zbtb7a/b-mediated Chromatin Remodeling. Nature Cell Biology.

  • He J#.,5. Cai S.#, Feng H.#, Cai B.#, Lin L.#, Mai Y., Fan Y., Zhu A., Huang H., Shi J., Li D., Wei Y., Li Yu., Zhao Y., Pan Y., Liu H., Mo X., He X., Cao S., Hu F., Zhao J., Wang J., Zhong N., Chen X., Deng X., Chen J., Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients. Protein & Cell.

  • Liu X.#, Zhu A.#, He J.#, Chen Z.#, Liu L.#, Xu Y.#, Ye F., Feng H., Luo L., Cai B., Mai Y., Lin L., Zhuang Z., Chen S., Shi J., Wen L., Wei Y., Zhuo J., Zhao Y., Li F., Wei X., Chen D., Zhang X., Zhong N., Huang Y., Liu H., Wang J., Xu X., Wang J., Chen R., Chen X., Zhong N., Zhao J., Li Y., Zhao J., Chen J., Single-Cell Analysis Reveals Macrophage-Driven T Cell Dysfunction in Severe COVID-19 Patients. medRxiv.

    • 2019
  • He J., Fu X., Zhang M., He F., Li W., Abdul M., Zhou J., Sun L., Chang C., Li Y., Liu H., Wu K., Babrinde I., Zhuang Q., Loh Y-H., Chen J., Esteban M., Hutchins A.P., Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications.

    • RESEARCH INTERESTS

    Epigenetics Control Transposable Elements (TEs)

    We aim to figure out how TEs are regulated by chromatin modifications in the genome- wide scale. By combining the TEs epigenomic landscape summarized through large-scaled ChIP-seq data mining with genome-wide screen, we try to uncover class-specific regulators of TEs transcription in different cell types.

    TEs Control Cell Fate Transition

    Presented TEs expression diverse between different cell fate branches by scRNA-seq during cell fate transition. Combination bioinformatic analysis of multi-omics data and experimental validation show how TEs control cell fate commitment. And also focous how epigenetic modification regulate cell fate decision through control of TEs.